Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 126-38-5, name is 1-Bromo-2,2-dimethoxypropane, A new synthetic method of this compound is introduced below., Recommanded Product: 1-Bromo-2,2-dimethoxypropane
Step B: To a suspension of 5-chloro-3-(trifluoromethyl)pyrazin-2-amine (0.77 g, 3.8 mmol) in iPrOH (6 ml) was added l-bromo-2,2-dimethoxypropane (0.57 ml, 4.2 mmol), pyridinium para-toluene sulfonic acid (0.1 g, 0.4 mmol) and the mixture heated to 100C in a sealed tube for 96h. The reaction was diluted with DCM, washed with saturated sodium hydrogen carbonate solution, dried (Na2S04) and concentrated. Purification by flash column chromatography on silica gel (EtOAc: Hept 3:7-1:0) afforded the titled product as a brown powder (0.15 g, 17%). MS (m/e): 236.1. (M+H+, CI)
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; GREEN, Luke; PINARD, Emmanuel; RATNI, Hasane; WILLIAMSON, Patrick; (95 pag.)WO2015/197503; (2015); A1;,
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