Reference of 41789-95-1,Some common heterocyclic compound, 41789-95-1, name is 1-(3-Methoxyphenyl)-N-methylmethanamine, molecular formula is C9H13NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: To a solution of compound 1 (1.18 g, 4 mmol) in THF 30 mL was added TEA (1.1 mL, 8 mmol) and series amine (8 mmol) dropwise with stirring. The reaction mixture was refluxed for 6 h. The mixture was concentrated and extracted with ethyl acetate, dried over MgSO4, and the solvent was removed in vacuo. The formed precipitate was filtered off and dried in vacuo. Recrystallization from hexane and ethyl acetate, washed with acetone.
The synthetic route of 41789-95-1 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Chen, Chun-Liang; Chang, Deh-Ming; Chen, Tsung-Chih; Lee, Chia-Chung; Hsieh, Hsi-Hsien; Huang, Fong-Chun; Huang, Kuo-Feng; Guh, Jih-Hwa; Lin, Jing-Jer; Huang, Hsu-Shan; European Journal of Medicinal Chemistry; vol. 60; (2013); p. 29 – 41;,
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