Related Products of 41789-95-1, These common heterocyclic compound, 41789-95-1, name is 1-(3-Methoxyphenyl)-N-methylmethanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A mixture of 2.73 mmol appropriate alkyl halide (i.e., 17a-c, or18a-c), 0.6 g K2CO3 (4.34 mmol), and 0.6 g NaI (4.00 mmol) in ACN(12 mL) was mixed for 5 min in a 30 mL microwave reaction vessel.Then, 8.2 mmol appropriate amine derivative (i.e., 1-6, as shown inScheme 3) was added and the resulting content was mixed foradditional 2 min. The reaction vessel was capped, and insertedinside the microwave instrument (i.e., A CEM Model Single ModeMicrowave Instrument) and heated for 32 min at 105 C at thedynamic mode of the instrument automatically calibrating theradiation and temperature balance with respect to the change inpressure. Then, acetonitrile was distilled out under vacuum andthe residue thus obtained was mixed with 20 mL of K2CO3 solution(5.0%) and this mixture was heated at 60 C for 1 h. Then the mixturewas cooled down to room temperature and the aqueous phasewas extracted 3 times with 20 mL of ethylacetate. Combinedorganic extracts were dried over MgSO4 and concentrated underreduced pressure to give the product (i.e., free base). The free basewas dissolved in 10 mL acetone and HCl gas was continuouslypassed until HCl salt precipitation took place.
Statistics shows that 1-(3-Methoxyphenyl)-N-methylmethanamine is playing an increasingly important role. we look forward to future research findings about 41789-95-1.
Reference:
Article; Gulcan, Hayrettin Ozan; Unlu, Serdar; Esiringu, Ilker; Ercetin, Tugba; Sahin, Yasemin; Oz, Demet; Sahin, Mustafa Fethi; Bioorganic and Medicinal Chemistry; vol. 22; 19; (2014); p. 5141 – 5154;,
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