Adding a certain compound to certain chemical reactions, such as: 36865-41-5, name is 1-Bromo-3-methoxypropane, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 36865-41-5, Application In Synthesis of 1-Bromo-3-methoxypropane
To a suspension of 4-chloro-3-hydroxy-5-nitrobenzamide (1.00 g, 4.62 mmol) in DMF(15 mL) was added 1-bromo-3-methoxypropane (1.06 g, 6.93 mmol) and K2C03 (1.91 mg,13.9 mmol). The reaction mixture was stirred at 60 C in a sealed tube. After 3 hr, thereaction was cooled to RT and poured into water. The resulting light yellow precipitate wascollected by filtration and washed with diethyl ether to provide the title compound (1.1 g, 3.8mmol, 83 % yield). LCMS (LCMS Method D): Rt = 0.84 mi [M+H] = 289.0
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Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; CHARNLEY, Adam Kenneth; DARCY, Michael Gerard; DODSON, Jason W.; DONG, Xiaoyang; FAVRE, David; HUGHES, Terry Vincent; KANG, Jianxing; LEISTER, Lara Kathryn; LI, Yuehu; LIAN, Yiqian; MEHLMANN, John F.; NEVINS, Neysa; RAMANJULU, Joshi M.; ROMANO, Joseph J.; WANG, Gren Z.; YE, Guosen; ZHANG, Daohua; (489 pag.)WO2019/69269; (2019); A1;,
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