Adding a certain compound to certain chemical reactions, such as: 10541-78-3, name is 2-Methoxy-N-methylaniline, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 10541-78-3, Formula: C8H11NO
Phosgene (5 mL, 20% in toluene) was added to a stirred suspension of 6′-hydroxy-4,4-dimethyl-4,5-dihydro-3/-/-[1,3′]bipyridinyl-2,6-dione (0.47 g, 2.00 mmol) and triethylamine(0.29 mL, 2.00 mmol) in dichloromethane (10 mL). After stirring for 0.75 h at room tempera- ture, the solvent and excess phosgene were evaporated under reduced pressure, yielding awhite solid. The residue was dissolved in dichloromethane (10 mL) followed by the additionof 1,4-diazabicyclo[2.2.2]octane (224 mg, 2.00 mmol) and 2-methoxy-/V-methylaniline (0.27g, 2.00 mmol) and stirring was continued for 0.75 hours at room temperature. The solutionwas extracted with water and evaporated in vacuo. The residue was purified by flash columnchromatography (SiO2, gradient of 0-15% ethyl acetate in dichloromethane), yielding the titlecompound (260 mg, 33% yield) as a white solid.1H NMR (300 MHz, CDC13): 8 = 1.19 (s, 6H), 2.66 (s, 4H), 3.29 + 3.40 (2 x s, 3H), 3.86 (s,3H), 6.94 (m, 2H), 7.04-7.54 (m, 4H), 8.03 + 8.12 (d + s, 1H); HPLC-MS (Method A): m/z =398 (M+H)+; Rt = 3.62 min.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Methoxy-N-methylaniline, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; NOVO NORDISK A/S; WO2004/111031; (2004); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem