Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1535-73-5, name is 3-Trifluoromethoxyaniline, A new synthetic method of this compound is introduced below., Safety of 3-Trifluoromethoxyaniline
General procedure: If not commercially available, the corresponding anilide derivative was prepared according tothe procedure from Marsais and coworkers.3 To the aniline derivative (10 mmol, 1.0 equiv.)dissolved in CH2Cl2 (20 mL) was added triethylamine (1.5 mL, 11 mmol, 1.1 equiv.).Pivaloyl chloride (1.5 mL, 12 mmol, 1.2 equiv.) was added dropwise at 0 °C and the mixturewas stirred for 5 h at room temperature. The reaction was quenched with ice coldNH4Cl (50 mL) and the aqueous phase extracted with CH2Cl2 (3 x 20 mL). The combinedorganic phases were washed with sat. NaHCO3 (3 x 30 mL), dried over MgSO4 andconcentrated under reduced pressure. Pure product was obtained by purification by flashcolumn chromatography with a mixture of pentane and ethyl acetate.
The synthetic route of 1535-73-5 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Vasquez-Cespedes, Suhelen; Holtkamp, Michael; Karst, Uwe; Glorius, Frank; Synlett; vol. 28; 20; (2017); p. 2759 – 2764;,
Ether – Wikipedia,
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