In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 887581-09-1 as follows. category: ethers-buliding-blocks
Step 3: tert-butyl (2-bromo-5-methoxybenzyl)carbamate To a solution of 1-(2-bromo-5-methoxyphenyl)methanamine (3.2 mmol) in DCM (15 mL) was added BOC2O (3.2 mmol). The reaction mixture was allowed to stir at rt overnight and then concentrated. The residue was purified by column chromatography to give tert-butyl (2-bromo-5-methoxybenzyl)carbamate (3.1 mmol, 95%).
According to the analysis of related databases, 887581-09-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Millennium Pharmaceuticals, Inc.; US2008/171754; (2008); A1;,
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Ether | (C2H5)2O – PubChem