Synthetic Route of 109-85-3, The chemical industry reduces the impact on the environment during synthesis 109-85-3, name is 2-Methoxyethylamine, I believe this compound will play a more active role in future production and life.
To a solution of 2,7-dichlorothiazolo[4,5-d]pyrimidin-5-amine 10 (0.10 g, 0.45 mmol) and triethylamine (69 mul, 0.50 mmol) in dioxane (3 ml) was added 2-methoxyethylamine (39 mul, 0.45 mmol). The reaction mixture was heated at 70 C for 2 h. After cooling, the volatiles were removed under reduced pressure. The crude residue was purified by chromatography on silica gel (CH2Cl2/MeOH 40:1) affording the title compound as a white solid (0.11 g, 94%). Mp 236-237 C. 1H NMR (300 MHz, DMSO, 25 C): delta = 9.09 (s, 1H, NH), 6.71 (s, 2H, NH2), 3.52 (br s, 4H, CH2), 3.29 (s, 3H, CH3) ppm. 13C NMR (75 MHz, DMSO, 25 C): delta =171.8, 170.8, 162.3, 149.4, 107.6, 69.8, 57.9, 43.8 ppm. HRMS: calcd for C8H9ClN4O2S [M+H]+ 260.01347, found 260.03656.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Methoxyethylamine, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Jang, Mi-Yeon; Jonghe, Steven De; Segers, Kenneth; Anne, Jozef; Herdewijn, Piet; Bioorganic and Medicinal Chemistry; vol. 19; 1; (2011); p. 702 – 714;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem