These common heterocyclic compound, 1758-46-9, name is 2-Phenoxyethylamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 2-Phenoxyethylamine
[0332] A mixture of 2-phenoxyethan-1-amine (10 mmol, 1.0 equiv), 1H-pyrazole-1-carboxamidine hydrochloride (15 mmol, 1.5 equiv, 1 M) and DIPEA (1.5 equiv) in 1,4-dioxane/H20 (2:1) was refluxed for 8 hours, cooled down to r.t. and evaporated to dryness. Anorange oily residue was treated with water and resulting solution was saturated with solid K2C03 to induce the precipitation of free guanidine. Formed precipitate was filtered off, washed withcold water and dried on a rotary evaporator to afford a title compound. Yield: 0.878 g (49percent).
The synthetic route of 2-Phenoxyethylamine has been constantly updated, and we look forward to future research findings.
Reference:
Patent; EVERON BIOSCIENCES, INC.; GUDKOV, Andrei; POLINSKY, Alexander; BALAN, Vitaly; CHERNOVA, Olga; HALL, Brandon, M.; KOMAROB, Pavel, G.; KAZYULKIN, Denis, N.; (236 pag.)WO2017/189553; (2017); A1;,
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