A common compound: 645-36-3, name is 2,2-Diethoxyethanamine, belongs to ethers-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 645-36-3
A suspension of pyrimidine 116 (0.5 g, 2.27 mmol) in MeOH (25mL) was treated by dropwise addition of a soln of 2,2-diethoxyethylamine(395 muL, 23 mmol) in MeOH (5 mL). Na2CO3 (0.29 g,2.73 mmol) was added and the mixture was stirred at r.t. for 1 h.H2O (100 mL) was then added and the resulting precipitate was collectedby filtration, dried, and crystallized (hexane) to give a colorlesssolid; yield: 0.53 g (74%); mp 74-75 C.IR (KBr): 3332 (NH), 2222 (CN) cm-1.1H NMR (300 MHz, CDCl3): delta = 1.28 (t, J = 6.9 Hz, 6 H, 2 ¡Á CH3),2.56 (s, 3 H, SCH3), 3.60 (dq, 2J = 9.6 Hz, 3J = 6.9 Hz, 2 H,2 ¡Á CHAHBCH3), 3.70-3.84 (m, 4 H, NCH2 and 2 ¡Á CHAHBCH3),4.64 (t, J = 5.4 Hz, 1 H, OCH), 5.89 (t, J = 5.4 Hz, 1 H, NH).13C NMR (75 MHz, CDCl3): delta = 14.7, 15.6, 44.0, 63.5, 86.1, 100.2,113.8, 161.2, 161.5, 176.3.Anal. Calcd for C12H17ClN4O2S: C, 45.49; H, 5.41; found: C, 45.62;H, 5.57.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 645-36-3, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Juskenas, Robertas; Masevicius, Viktoras; Tumkevicius, Sigitas; Synthesis; vol. 45; 17; (2013); p. 2438 – 2446;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem