In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 36865-41-5 as follows. Quality Control of 1-Bromo-3-methoxypropane
A solution of PPh3 (42.8 g, 163.2 mmol) and 1-bromo-3-methoxypropane (25 g, 163.3 mmol) in toluene (70 mL) is heated at 150C in an autoclave for 44 h. After completion of the reaction, the mixture is filtered and the precipitate washed with toluene and dried under high vacuum for 4 h affording the title compound as a white powder: Rt (HPLC, Nucleosil C18, 10: 90-100: 0 CH3CN/H20 + 0. 1 % TFA within 5 min, then 100% CH3CN + 0. 1% TFA): 5.06 min.
According to the analysis of related databases, 36865-41-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2005/51911; (2005); A1;,
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