Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 93919-56-3, name is (4-(Trifluoromethoxy)phenyl)methanamine, A new synthetic method of this compound is introduced below., HPLC of Formula: C8H8F3NO
Step 4; 5-(2-phenyl-6-(4-(trifluoromethoxy)benzylcarbamoyl)qumolin-3-yl)pentanoic acid trifl oroacetate; To a solution of 1C (51 mg, 0.126 mmol) in DCM (5 mL) was added HATU (72 mg, 0.189 mmol) followed by DIPEA (81.3 mg, 0.629 mmol) and 4- (trifluoromethoxy)benylamine (38 uL, 0.25 mmol). The reaction mixture stirred at RT for 1 h. The reaction mixture was treated with TF A (3 mL), stirred at RT for 2 h and then concentrated to dryness under reduced pressure. Chromatography (5-100% EtOAc/hexanes) provided 1 (74 mg; Yield – 92%, LCMS (M+H) = 523).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; MERCK SHARP & DOHME CORP.; SCHERING CORPORATION; BOYCE, Christopher, W.; FEVRIER, Salem; MCCORMICK, Kevin, D.; PALANI, Anandan; ASLANIAN, Robert, G.; SILIPHAIVANH, Phieng; METHOT, Joey, L.; BROWN, William Colby; VACCARO, Henry; WO2012/87872; (2012); A1;,
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