Adding a certain compound to certain chemical reactions, such as: 38336-04-8, name is 2-(Benzyloxy)-1-ethanamine, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 38336-04-8, SDS of cas: 38336-04-8
In a sealable vial, a solution of compound 173 (0.71 g, 2.81 mmol) and 2-(benzyloxy)-l-ethaneamine (0.85 g, 5.62 mmol) in benzene (20 mL) was flushed with N2. The vial was sealed and heated at 80 C for 4 h. After cooled to room temperature, the reaction mixture was partitioned between sat. aq. KH2PQ4 (50 mL) and EtOAc (50 mL). The organic extract was washed with brine (50 mL), dried with MgSOr, filtered, and concentrated. The residue was purified by column chromatography (silica gel, eluting with 25% EtOAc in hexanes) to give compound 269e (0.91 g, 84% yield) as a light yellow oil. m/z = 386 (M+l).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-(Benzyloxy)-1-ethanamine, and friends who are interested can also refer to it.
Reference:
Patent; REATA PHARMACEUTICALS, INC.; JIANG, Xin; VISNICK, Melean; BENDER, Christopher, F.; BOLTON, Gary; CAPRATHE, Bradley; LEE, Chitase; KORNBERG, Brian; O’BRIEN, Patrick; HOTEMA, Martha, R.; (420 pag.)WO2019/241796; (2019); A1;,
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