Application of 1462-37-9, These common heterocyclic compound, 1462-37-9, name is ((2-Bromoethoxy)methyl)benzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Stage 1; – /V-{1-[2-(Benzyloxy)ethyl]piperidin-4-yl}-4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6- oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxybenzamide To a solution of Intermediate C (300mg, 0.59mmol) in DMF (3ml), was added benzyl-2- bromoethylether (0.09ml, 0.59mmol), K2CO3 (163mg, 1.18mmol) and NaI (catalytic amount). The reaction mixture was stirred for 18 hours at 50 °C, cooled to RT and partitioned between EtOAc (10ml) and water (10ml). The aqueous layer was re-extracted with EtOAc (2 x 10ml) and the combined organic layers were washed with water (2 x 10ml), brine (2 x 15mL), dried (MgSO4), and concentrated under reduced pressure. Purification by column chromatography (5 – 10percent MeOH in DCM) afforded the title product (213mg, 56percent). ESMS m/z 642 [M+H]+
Statistics shows that ((2-Bromoethoxy)methyl)benzene is playing an increasingly important role. we look forward to future research findings about 1462-37-9.
Reference:
Patent; CHROMA THERAPEUTICS LTD.; WO2008/50078; (2008); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem