Adding a certain compound to certain chemical reactions, such as: 402-07-3, name is 4-Bromo-3-methoxybenzotrifluoride, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 402-07-3, Recommanded Product: 402-07-3
General procedure: A microwave vial was charged with N-(4-methoxybenzyl)-N-(thiazol-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide (28) (0.100 g, 0.24 mmol), xantphos (0.028 g, 0.048 mmol), 4-bromo-3-methoxybenzonitrile (0.051 g, 0.24 mmol), Pd2(dba)3 (0.022 g, 0.024 mmol) and sodium tert-butoxide (0.046 g, 0.48 mmol). The mixture was diluted with toluene (2.5 mL), purged with nitrogen, and heated at 130 C in the microwave for 30 min. After completion, the mixture was cooled to room temperature and trifluoroacetic acid (1.0 mL) was added. After stirring for 45 min at room temperature, the reaction was filtered through a plug of Celite, washing with DCM 10 mL). The filtrate was concentrated and purified by reverse-phase preparative HPLC using 0.1% TFA in CH3CN/H2O, gradient 25% to 90% over 15 min to provide 4-(4-cyano-2-methoxyphenyl)-N-(thiazol-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide 10 as a salt with trifluoroacetate (0.073 g, 0.14 mmol, 56 % yield) as an orange solid.
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Reference:
Article; La, Daniel S.; Peterson, Emily A.; Bode, Christiane; Boezio, Alessandro A.; Bregman, Howard; Chu-Moyer, Margaret Y.; Coats, James; DiMauro, Erin F.; Dineen, Thomas A.; Du, Bingfan; Gao, Hua; Graceffa, Russell; Gunaydin, Hakan; Guzman-Perez, Angel; Fremeau, Robert; Huang, Xin; Ilch, Christopher; Kornecook, Thomas J.; Kreiman, Charles; Ligutti, Joseph; Jasmine Lin, Min-Hwa; McDermott, Jeff S.; Marx, Isaac; Matson, David J.; McDonough, Stefan I.; Moyer, Bryan D.; Nho Nguyen, Hanh; Taborn, Kristin; Yu, Violeta; Weiss, Matthew M.; Bioorganic and Medicinal Chemistry Letters; vol. 27; 15; (2017); p. 3477 – 3485;,
Ether – Wikipedia,
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