Adding a certain compound to certain chemical reactions, such as: 1462-37-9, name is ((2-Bromoethoxy)methyl)benzene, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1462-37-9, Safety of ((2-Bromoethoxy)methyl)benzene
[00405] Step A: To a solution of ((2-bromoethoxy)methyl)benzene (1.34 mL, 7.6 mmol) in diethyl ether (20 mL) were added magnesium turnings (0.185 g, 7.6 mmol) and the mixture was heated at reflux for 30 min. The mixture was cooled to -20 0C, and a solution of (4-(lH-pyrazol-5-ylamino)pyirolo[l,2-f][l,2,4]triazin-2-yichi4- fiuorophenyl)methanone (700 mg, 2.17 mmol) in THF (20 mL) was added. The mixture was stirred at -20 °C for 1 hour, then aqueous ammonium chloride was added, and the precipitated solid was collected by filtration, washing with water. The crude solid was purified using chromatography on silica gel eluting with 2-8percent MeOH/DCM to afford 1 -(4-( 1 H-pyrazol-5-ylamino)pyrrolo [ 1 ,2-fJ [ 1 ,2,4]triazin-2-yl)-4- (benzyloxy)-l-(4-fluorophenyl)butan-l-ol (625 mg, 85percent).
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Reference:
Patent; AMBIT BIOSCIENCES CORPORATION; ABRAHAM, Sunny; CHAO, Qi; HADD. Michael, J.; HOLLADAY, Mark, W.; LIU, Gang; NAMBU, Mitchell, D.; SETTI, Eduardo; WO2010/2472; (2010); A1;,
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