Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6298-96-0, name is 1-(4-Methoxyphenyl)ethylamine, A new synthetic method of this compound is introduced below., Recommanded Product: 6298-96-0
A mixture of (S)-1-(4-methoxyphenyl)-ethylamine (475 mg) and 6-chloropurine riboside (300 mg) in PrOH (70 ml) was heated to 70C and reacted for 8 h. After evaporation of the reaction mixture, the residue was separated by column chromatography over Sephadex LH-20 gel and eluted with ethanol to yield N6-[(S)-1-(4-methoxyphenyl)-ethyl]-adenosine(345 mg) as a white solid: positive ESIMS m/z 402 [M + H]+ and 424 [M + Na]+; 1H NMR (300 MHz, DMSO-d6): the adenosine moiety delta 8.38 (1H, s, H-2), 8.23 (1H, brs, -NH), 8.18 (1H, s, H-8), 5.90 (1H, d, J= 6.3 Hz, H-1′), 5.46 (1H, d, J= 6.3 Hz, -OH), 5.42 (1H, m, -OH), 5.20 (1H, d, J= 4.5 Hz, -OH), 4.61 (1H, m, H-2′), 4.16 (1H, m, H-3′), 3.98 (1H, m, H-4′), 3.66 (1H, m, H-5’a), 3.54 (1H, m, H-5’b); the (S)-1-(4-methoxyphenyl)-ethyl moiety delta 7.35 (1H, d, J = 8.4 Hz, H-2′, H-6′), 6.84 (1H, d, J = 8.4 Hz, H-3′, H-5′), 5.48 (1H, m, H-7′), 3.71 (3H, s, -OCH3), 1.51 (3H, d, 7.2Hz, H-8′); 13C NMR (75 MHz, DMSO-d6): the adenosine moiety delta,153.9 (s, C-6), 152.3 (d, C-2), 148.6 (s, C-4), 139.8 (d, C-8), 119.7 (s, C-5), 88.0 (d, C-1′), 85.9 (d, C-4′), 73.6 (d, C-2′), 70.7 (d, C-3′), 61.7 (t, C-5′); the (S)-1-(4-methoxyphenyl)-ethyl moiety delta 158.0 (s, C-4′), 137.1 (s, C-1′), 127.3 (d, C-2′, C-6′), 113.6 (d, C-3′, C-5′), 55.0 (q, -OCH3), 48.2 (d, C-7′), 22.5 (q, C-8′)o
The synthetic route of 6298-96-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES; EP2511283; (2012); A1;,
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