In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 10541-78-3, name is 2-Methoxy-N-methylaniline belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 2-Methoxy-N-methylaniline
(a) 5-Methoxy-4-methyl-2H-benzo[e][1 ,2,4]thiadiazin-3(4H)-one 1 ,1 -dioxide (2913) To a vigorously stirred solution of chlorosulfonyl isocyanate (1 .52 mL) in 1 -nitropropane (20 mL) at -40 C, under nitrogen, was slowly added over 10 min a solution of 2-methoxy-N- methylaniline (2.0 g) in 1 -nitropropane (10 mL). The mixture was then allowed to warm to RT and stirred for 60 min. Anhydrous aluminum chloride (2.53 g) was added and the mixture was then allowed to stir at 120 C for 2 h. The hot solution was poured onto ice (~40 g) and, after stirring and complete melting of ice, the resulting precipitate was collected by filtration and rinsed with water (5 mL). The insoluble crude material was suspended in an aqueous solution of NaHC03 (1 .5 g/30 mL) and heated until most of the precipitate was dissolved. The suspension was filtered, and the filtrate was adjusted to pH ~1 with 6 N HCI. The resulting solid was collected by filtration, rinsed with water, and dried to give the titled compound (0.79 g) as a yellowish solid. LCMS m/z 242.9 (M+H); 1H NMR (400 MHz, DMSO-c/e) delta ppm 3.40 (s, 3H), 3.92 (s, 3H), 7.38-7.50 (m, 3H).
The synthetic route of 10541-78-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; ADAMS, Jerry Leroy; ATOR, Laura E.; DUFFY, Kevin J.; GRAYBILL, Todd L.; KIESOW, Terence John; LIAN, Yiqian; MOORE, Michael Lee; RALPH, Jeffrey M.; RIDGERS, Lance Howard; (370 pag.)WO2017/98421; (2017); A1;,
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