These common heterocyclic compound, 588-96-5, name is p-Bromophenetole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of p-Bromophenetole
A mixture of 4-bromophenetole (1.0 mmol), phenylboronic acid (1.2 mmol), organic solvents (6 mL), bases (2.0 mmol) and 0.5 mol % of catalyst was stirredat 80 C under air. After the reaction, the catalyst was separated by filtration. The filtrate was dried over Na2SO4 and filtered. The products were quantified by GC-MS analysis (Shimadzu GCMS-QP5050A equipped with a 0.25mm × 30 m DB-WAX capillary column). The typical GCMS analysis program was as follows: initial column temperature 100 C, hold 2 min, ramp temperature to 280 C at 15 C/min, and hold for 5 min.
The synthetic route of p-Bromophenetole has been constantly updated, and we look forward to future research findings.
Reference:
Article; Feng, Zhi-Qiang; Yang, Xiao-Li; Ye, Yuan-Feng; Hao, Lin-Yun; Bulletin of the Korean Chemical Society; vol. 35; 4; (2014); p. 1121 – 1127;,
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