The important role of 2752-17-2

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2752-17-2 as follows. Product Details of 2752-17-2

5LlO-l,2-HOPOBn; To a solution of l ,2-HOPO(Bn)-thiazolide (644 mg, 2.1 mmol) in dry methylene chloride (20 mL), was added neat 5LIO-amine ( 104 mg, 1.0 mmol). The mixture was stirred overnight, after which time the solvent was removed and the residue was loaded onto a flash silica column. Elution with 2-6% methanol in methylene chloride allowed for the separation and isolation of the benzyl-protected 5L1O- 1 , 2-HOPO(Bn) to give a pale yellow oil (447 mg. 85 % based on amine). [0251] 1 H NMR (500MHz, CDCl3): delta 3.22(s, 8H, CH2), 5.24(s, 4H, benzyl CH2), 6.26(dd, J= I, .2 Hz, 2H, HOPO H), 6.3 l (d, 2H, J = 9.0 Hz, HOPO H), 7.24(dd, 2H, J= 9.0, 2 Hz, ArH), 7.26-7.45(m, 12H, ArH), 7.74(s,br, 2H, amideH). 1 3C NMR ( 125 MHz, CDCI3): delta 38.8, 68.1 , 78.2, 104.7, 121.7, 127.7, 128.3, 129.0, 132.9, 138.3, 143.2, 157.8, 160.0. MS(FAB+): 559.2 (MH ‘).

According to the analysis of related databases, 2752-17-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; WO2008/8797; (2008); A2;,
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