Related Products of 41365-75-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 41365-75-7, name is 1-Amino-3,3-diethoxypropane, This compound has unique chemical properties. The synthetic route is as follows.
Prepared according to General Procedure B from THP-protected bromophenol S1 (10.0 g, 38.9mmol), CuI (0.99 g, 5.84 mmol), L-proline (1.34 g, 11.7 mmol), K2CO3 (10.7 g, 77.8 mmol) andamino-3,3-diethoxypropane (9.43 mL, 58.4 mmol) in DMSO (55 mL). The reaction was stirred at 90C for 24 h and then purified by flash chromatography (SiO2, 0.5% Et3N in 5:1?1:1, 40-60 Cpetroleum ether/diethyl ether) to yield the title compound S2 (10.4 g, 32.2 mmol, 83% yield) as anorange oil; Rf 0.45 (5:1, 40-60 C petroleum ether/diethyl ether); numax/cm-1 (film) 3386, 2971, 2940,2875, 1616, 1510, 1226, 1201; deltaH (400 MHz, CDCl3) 6.92 (2H, d, J = 8.8 Hz), 6.55 (2H, d, J = 8.8Hz), 5.23 (1H, t, J = 3.3 Hz), 4.62 (1H, t, J = 5.5 Hz), 3.99-3.93 (1H, m, J = 3.3 Hz), 3.81 (1H, bs),3.71-3.64 (2H, m), 3.60-3.55 (1H, m), 3.54-3.47 (2H, m), 3.17 (2H, t, J = 7.0 Hz), 2.03-1.91 (3H,m), 1.85-1.81 (2H, m), 1.70-1.56 (3H, m), 1.22 (6H, t, J = 7.0 Hz); deltaC (100 MHz, CDCl3) 149.3,143.7, 118.2, 113.8, 102.2, 97.7, 62.1, 61.5, 40.9, 33.3, 30.6, 25.3, 19.1, 15.3; HRMS (ESI) calculatedfor C18H30NO4 [M+H]+ m/z 324.2169, found 324.2170.
The chemical industry reduces the impact on the environment during synthesis 1-Amino-3,3-diethoxypropane. I believe this compound will play a more active role in future production and life.
Reference:
Article; Williamson, Alice E.; Ngouansavanh, Tifelle; Pace, Robert D. M.; Allen, Anna E.; Cuthbertson, James D.; Gaunt, Matthew J.; Synlett; vol. 27; 1; (2016); p. 116 – 120;,
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