Electric Literature of 1535-73-5,Some common heterocyclic compound, 1535-73-5, name is 3-Trifluoromethoxyaniline, molecular formula is C7H6F3NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A) [3-(trifluoromethoxy)phenyl]hydrazine hydrochloride 3-(Trifluoromethoxy)aniline (3.68 ml) was dissolved in 6 M hydrochloric acid (71 ml), and an aqueous solution (4.7 ml) of sodium nitrite (2.08 g) was added dropwise over 20 min at -5° C. Tin (II) chloride (1.954 ml) was dissolved in 6 M hydrochloric acid (25 ml), and the solution was cooled to -5° C., and added quickly to the above-mentioned reaction mixture at -5° C. The mixture was stirred at -5° C. for 2 hr, and the precipitated solid was collected by filtration, washed with 0.1M hydrochloric acid, and dried under reduced pressure to give the title compound (2.72 g). 1H NMR (300 MHz, CDCl3) delta 6.81-7.03 (3H, m), 7.41 (1H, t, J=8.3 Hz), 8.64 (1H, br. s.), 10.35 (2H, br. s.)
The synthetic route of 1535-73-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Yoshikawa, Masato; Suzuki, Shinkichi; Hasui, Tomoaki; Fushimi, Makoto; Kunitomo, Jun; Kamisaki, Haruhi; Taniguchi, Takahiko; US2013/150344; (2013); A1;,
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