Some tips on 1484-26-0

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1484-26-0.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1484-26-0, name is 3-Benzyloxyaniline, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 1484-26-0

A suspension of 2-chloro-5-bromopyrimidine (300 mg, 1.55 mol), 3-benzyloxyaniline (680 mg, 3.41 mmol), tpi’5′(dibenzylideneacetone)palladium(0) (56 mg, 61.1 mumol), 4,5-fos(diphenylphosphino)-9,9-dimethylxanthene (71 mg, 122.7 mumol) and cesium carbonate (1.21 g, 3.72 mmol) in degassed 1,4-dioxan (7 mL) was heated at 80°C for 4 days. After cooling to room temperature, the mixture was diluted with ethyl acetate and washed with water, 0.5 M hydrochloric acid and brine. The organic phase was dried (MgSO4) and the solvent removed under reduced pressure to give a thick orange- brown oil. The crude product was purified by column chromatography on silica gel eluting with 1:3 ethyl acetate/petroleum ether to afford the title compound as an off- white solid (203 mg, 28 percent). deltaH (4-DMSO, 400 MHz): 5.08 (2 H, s), 5.10 (2 H, s), 6.42-6.50 (3 H, m), 6.58 (1 H, d), 7.11 (1 H, t), 7.20 (1 H, t), 7.30-7.50 (11 H, m), 7.62 (1 H, s), 7.91 (1 H, s), 8.38 (2 H, s) and 9.53 (1 H, s).LCMS (ES+): 475 (MH+, 100 percent).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1484-26-0.

Reference:
Patent; SENEXIS LIMITED; WO2007/125351; (2007); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem