Application of 366-99-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 366-99-4, name is 3-Fluoro-4-methoxyaniline belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Acetic anhydride (159 mmol, 1 .495 eq) is added to 3-fluoro-4-methoxyaniline (106 mmol, 1 eq) at RT and the resulting mixture is stirred at this temperature for 30 minutes. Nitric acid (156 mmol, 1.57 eq) is then added dropwise and the resulting suspension is stirred at RT for 3 h. Water is added to quench the reaction, the resulting solid collected by filtration and dried under vacuum. A/-(5-Fluoro-4-methoxy-2-nitrophenyl)acetamide (24.2 g) is obtained as a yellow solid. LC-MS (conditions F): tR = 0.71 min, [M + 1 + CH3CN]+ = 270.25.
The synthetic route of 3-Fluoro-4-methoxyaniline has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ACTELION PHARMACEUTICALS LTD; BOSS, Christoph; BROTSCHI, Christine; HEIDMANN, Bibia; SIFFERLEN, Thierry; WILLIAMS, Jodi T.; WO2012/85857; (2012); A1;,
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