Reference of 707-07-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 707-07-3, name is (Trimethoxymethyl)benzene, This compound has unique chemical properties. The synthetic route is as follows.
4-(2-Azidoethyl)phenyl 4-0-benzoyl-2,6-di-0-benzyl-p-D-galactopyranoside (16)To a solution of 15 (1 .17 g, 2.31 mmol) in toluene (15 mL) were added trimethylortho- benzoate (0.64 mL, 3.72 mmol) and p-TsOH (1 18 mg, 0.62 mmol). The mixture was stirred at 45C overnight, then concentrated and the residue dissolved in 90% aq AcOH (15 mL). The solution was stirred for 2 h at 60C, concentrated, and the residue was purified by flash chromatography (petroleum ether/EtOAc, 9:1 to 7:3) to yield 16 (1 .30 g, 2.14 mmol, 93%) as a colorless oil. (0231) [a]D20 -8.4 (c 1.00, CHCI3); 1H NMR (500 MHz, CDCI3): delta 2.83 (t, J = 7.3 Hz, 2H, (0232) CH2CH2N3), 3.44 (t, J = 7.3 Hz, 2H, CH2CH2N3) 3.60-3.66 (m, 2H, H-6), 3.87 (dd, J = 7.4, (0233) 9.6 Hz, 1 H, H-2), 3.92 (dd, J = 3.5, 9.6 Hz, 1 H, H-3), 3.96 (t, J = 6.2 Hz, 1 H, H-5), 4.41 , 4.48 (A, B of AB, J = 1 1 .7 Hz, 2H, CH2Ph), 4.78 (A of AB, J = 1 1 .2 Hz, 1 H, CH2Ph), 4.99- (0234) 5.07 (m, 2H, H-1 , CH2Ph), 5.63 (d, J = 2.8 Hz, 1 H, H-4), 7.06, 7.12 (AA, BB’ of AA’BB’, J = 8.5 Hz, 4H, C6H4), 7.18-7.35 (m, 10H, 2 C6H5), 7.43 (t, J = 7.8 Hz, 2H, C6H5), 7.56 (t, J = 7.4 Hz, 1 H, C6H5), 8.04-8.09 (m, 2H, C6H5); 13C NMR (126 MHz, CDCI3): delta 34.62 (0235) (CH2CH2N3), 52.63 (CH2CH2N3), 68.61 (C-6), 70.25 (C-4), 72.21 (C-3), 73.28 (C-5), 73.71 , 75.13 (2 CH2Ph), 79.15 (C-2), 101 .89 (C-1 ), 1 17.07 (2C, C6H4), 127.76, 127.78, 128.04, 128.29, 128.39, 128.49, 128.58, 129.57 (12C, 3 C6H5), 129.93 (2C, C6H4), 130.10, 132.46, 133.38, 137.79 (6C, 3 C6H5), 138.06, 156.17 (C6H4), 166.38 (CO); ESI-MS: m/z: calcd for C35H35N3Na07 [M+Na]+: 532.24, found: 532.28; IR (film): 2102 cm”1 (N3).
The chemical industry reduces the impact on the environment during synthesis (Trimethoxymethyl)benzene. I believe this compound will play a more active role in future production and life.
Reference:
Patent; UNIVERSITAET BASEL; ERNST, Beat; HERRENDORFF, Ruben; STECK, Andreas; YANG, Fan; WO2015/136027; (2015); A1;,
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