In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5414-19-7, name is 1-Bromo-2-(2-bromoethoxy)ethane belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Quality Control of 1-Bromo-2-(2-bromoethoxy)ethane
2,5-Diamino-3-chloro-benzonitrile (387 mg), bis- (2-bromoethyl) ether (0.35 mL) and N, N-diisopropyl-ethylamine (1.25 mL) were mixed in N, N-dimethylformamide (4 mL) and heated to 180C for 30 minutes in a sealed microwave process vial. Saturated aqueous bicarbonate (20 mL) was added and the crude mixture was extracted with ethyl acetate (20 mL). The organic phase was washed with water (20 mL) and brine (20 mL), dried over sodium sulfate and concentrated in vacuo to furnish 0.50 g (91%) of the title compound as a brown solid. LC-MS (m/z) 238 (MH+) ; tR = 2. 31, (UV, ELSD) 85%, 95%. 1H NMR (500 MHz, DMSO-d6): 2.97 (m, 4H), 3.69 (m, 4H), 5.59 (s, 2H), 7.04 (d, 1H), 7.29 (d, 1H).
The synthetic route of 5414-19-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; H. LUNDBECK A/S; WO2005/87754; (2005); A1;,
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