Reference of 36865-41-5, These common heterocyclic compound, 36865-41-5, name is 1-Bromo-3-methoxypropane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a stirred solution of [2], X=Br (1 wt, 1 mol eq.) in DMF (5 vol.) was added (0229) portionwise CS2CO3 (2.34 wt, 1.5 mol eq.) at room temperature, and then the reaction mixture was continued on stirring for 10 min. Then, l-bromo-3-methoxypropane (0.65 wt, 1.2 mol eq.) was added dropwise to the reaction mixture at room temperature and stirred for 16 h at the same temperature. The reaction was monitored by TLC. After completion of reaction, the resultant reaction mixture was diluted with water (3.2 vol.), and stirring was continued for 30 min to produce the solid, which was filtered, washed with water and dried under reduced pressure to obtain the product 5-bromo-2-chloro-3-(3-methoxypropoxy)pyridine [3], X=Br as off-white solid. 1H-NMR [300MHz, DMSO-d6]: d 8.10 (d, 1H, J= 1.5 Hz), 7.87 (d, 1H, J= 1.5 Hz), 4.15 (t, 2H, J= 6.0 Hz), 3.45(t, 2H, J= 6.4 Hz), 3.22 (s, 3H), 1.95 (quint, 2H, 7=6.4, 12.4 Hz).
Statistics shows that 1-Bromo-3-methoxypropane is playing an increasingly important role. we look forward to future research findings about 36865-41-5.
Reference:
Patent; ARBUTUS BIOPHARMA CORPORATION; CHEN, Shuai; DORSEY, Bruce D.; GOTCHEV, Dimitar B.; NGUYEN, Duyan; PALLERLA, Mahesh Kumar; PAMULAPATI, Ganapati Reddy; (76 pag.)WO2019/200109; (2019); A1;,
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