Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2393-23-9, name is 4-Methoxybenzylamine, A new synthetic method of this compound is introduced below., Safety of 4-Methoxybenzylamine
3. Bis (4-methoxybenzyl) amine Reflux a solution of 4-methoxybenzylamine (25 g, 182 rnmol) and 4-methoxybenzaldehyde(22 mL, 182 rnmol) in 200 mL EtOH for 3 hours. Evaporate the solvent under reduced pressure to give the intermediate imine as a pale brown oil. Immediately, dissolve the intermediate imine in dry MeOH, cool to 00C, and add NaBH4 (6.9 g, 182 mmol) in portions over 30 minutes. Remove the ice bath, stir the reaction mixture at 4O0C for 40 minutes and reflux for 2 hours. After stirring at room temperature overnight, remove the solvent under vacuum, dissolve the residual oil in CH2Cl2 (200 mL) and wash with 5% NaHCO3 (10 mL). Dry the CH2Cl2 layer (Na2SO4), filter, and concentrate to afford the title product as a yellow oil, which solidifies while standing in the refrigerator. 1H NMR (400 MHz, CDCl3) delta 7.25 (m, 4H), 6.87 (m, 4H), 3.8 (s, 6H), 3.75 (d, 4H, J=8.8 Hz), 1.54 (bs, IH).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; NEUROGEN CORPORATION; WO2006/42289; (2006); A2;,
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