150-78-7, name is 1,4-Dimethoxybenzene, belongs to ethers-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. SDS of cas: 150-78-7
Paraformaldehyde (Aldrich, 4.27 g, 144.75 mmol) and HBr/AcOH (Fluka, 33%, 30 mL) were added slowly to a stuffed solution of 1,4-dimethoxybenzene (Aldrich, 10.00 g, 72.37 mmol) in glacial acetic acid (Fisher, 50 mL). The mixture was stirred at 50C for one hour, allowed to cool to room temperature, and then hydrolyzed in water (200 mL). The white solid was collected by filtration, suspended in CHC13 (50 mL), and refluxed for 10 mm. After cooling to room temperature, the white solid was again collected by filtration and washed with water (15.75 g, 67%). NMR spectra were obtained experimentally to confirm the chemical structure of the resulting compound and its purity. NMR results were as follows: ?H NMR (300 MHz, CDC13) 6:6.88 (s, 2H), 4.54 (s, 4H), 3.87 (s, 6H) ppm.
The synthetic route of 150-78-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ROBERT BOSCH GMBH; MARUNIAK, Autumn; AHMAD, Habib; RAGHUNATHAN, Ashwin; JOHNSON, Christopher; KAVUSI, Sam; FOMINA, Nadezda; LANG, Christoph; (170 pag.)WO2017/5587; (2017); A1;,
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