Related Products of 41406-00-2, A common heterocyclic compound, 41406-00-2, name is 3-Isopropoxyaniline, molecular formula is C9H13NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: Thiazole bisamide compounds were prepared in the same manner as in Examples 1-28 except that the R3 diphenyl ether group was substituted with a substituted phenyl group as shown in Table 5, The results of the prepared products of formula as (I-3), as well as the numbers of the prepared compounds, R1, R2 and R7 and the yields thereof are shown in Table 5. The intermediate of formula (II) (0.5 mmol), 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDCI, 0.6 mmol), hydroxybenzotriazole (HOBt, 0.6 mmol) was dissolved in 5 mL of N, N-dimethylformamide, the reaction temperature 25 deg. C 1h; Then, the reactant (0.6 mmol) represented by R3-NH2 was added to the above solution, the reaction temperature was 25 deg. C 72h; after completion of the reaction, the solvent was removed under reduced pressure, column chromatography to obtain the target product, thiazole bisamide compound.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Central China Normal University; Yang, Guangfu; Chen, Cheng; Chen, Yanqing; Xiong, Maoqian; (30 pag.)CN106316977; (2017); A;,
Ether – Wikipedia,
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