Application of 41789-95-1, A common heterocyclic compound, 41789-95-1, name is 1-(3-Methoxyphenyl)-N-methylmethanamine, molecular formula is C9H13NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step B: To a solution of the above amine (6.2 g, 41.00 mmol) from Step A in methylene chloride (100 mL) was added 3,4-dichlorophenacyl bromide (10.0 g, 37.3 mmol) and the resulting mixture was stirred at 0 0C for 1 hour prior to the addition of triethylamine (5.20 mL, 37.31 mmol), followed by 1 hour stirring at 0 0C. The reaction mixture was diluted with water (100 mL) then the aqueous phase was extracted with additional methylene chloride (3 x 75 mL). The combined extracts were dried over sodium sulfate, filtered, and concentrated to afford l-(3,4-dichlorophenyl)-2-((3- methoxybenzyl)(methyl)amino)ethanone (15.08 g) as a light yellow oil, which was used in the next step without further purification: 1H NMR (500 MHz, CDCl3) delta 8.08 (d, J = 2.0 Hz, IH), 7.78 (dd, J = 8.5; 2.0 Hz, IH), 7.50 (d, J = 8.5 Hz, IH), 7.25 (d, J= 8.5 Hz, IH), 6.90 (d, J= 7.5 Hz, IH), 6.87 (d, J= 2.5 Hz, IH), 6.82 (dd, J= 8.0; 2.5 Hz, IH), 3.79 (s, 3H), 3.66 (s, 2H), 3.60 (s, 2H), 2.33 (s, 3H).
The synthetic route of 41789-95-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ALBANY MOLECULAR RESERCH, INC.; WO2010/132442; (2010); A1;,
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