Adding a certain compound to certain chemical reactions, such as: 589-10-6, name is (2-Bromoethoxy)benzene, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 589-10-6, name: (2-Bromoethoxy)benzene
Compound 99 (100 mg, 0.371 mmol) to DCM (2 mL) the solution was dissolved in methyl isothiocyanate (30.0 , 0.446 mmol) was slowly added dropwise in a 0 and then, at room temperature two hours then stirred dongan. After checking the completion of the reaction by TLC, the solution was diluted with DCM and extracted with brine. The organic layer was dried over anhydrous Na2SO4, concentrated and filtered. The concentrated filtrate was purified by column chromatography (Hex: EtOAc = 1: 2) to give Compound 101 was synthesized via a (69.3 mg, 55%, colorless oil).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, (2-Bromoethoxy)benzene, and friends who are interested can also refer to it.
Reference:
Patent; Korea Institute of Science and Technology; Ulsan University Academic Cooperation; Kim, Dong Jin; Nam, Gil Soo; Choe, Gyung Ir; Park, Woong Saw; Kim, Young Soo; Pyeon, Sung Lim; Hwang, Hyun Suk; Mun, Doo Hyun; Hwang, Ohn Yu; Sim, Young Sun; Kim, Jin Woo; Kim, Yun Gyung; Kang, Yong Gu; Park, Gi Tuk; (106 pag.)KR101525019; (2015); B1;,
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