Application of 6850-60-8, These common heterocyclic compound, 6850-60-8, name is (4-Ethoxyphenyl)methanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: To a solution of 18 (75 mg, 0.25 mmol) in 5 mL EtOH in sealed tubewas added various anilines or benzylamines, the mixture was stirred at150 C. After completion, the reaction was cooled to room temperature.In the cases of solid precipitation in the reaction, the precipitates werecollected by filtration, washed with cold EtOH and dried to afford thefinal products. When no solid precipitated in the reaction, the solventwas removed in vacuo and then purified by flash column chromatographyto afford the final products.
Statistics shows that (4-Ethoxyphenyl)methanamine is playing an increasingly important role. we look forward to future research findings about 6850-60-8.
Reference:
Article; Li, Wenlong; Yin, Ying; Shuai, Wen; Xu, Feijie; Yao, Hong; Liu, Jie; Cheng, Keguang; Xu, Jinyi; Zhu, Zheying; Xu, Shengtao; Bioorganic Chemistry; vol. 83; (2019); p. 380 – 390;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem