In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 54149-17-6 as follows. 54149-17-6
Compound 1 (2.2 g, 8.7 mmol) was dissolved in DMSO (50 ml), potassium carbonate (3.6 g, 26.1 mmol) was added, and the mixture was stirred at room temperature for 30 minutes.Next, 2- (2-methoxyethoxy) ethyl bromide (manufactured by Tokyo Chemical Industry Co., Ltd.: 4.8 g, 26.1 mmol) was added and the mixture was stirred at room temperature for 12 hours.After the reaction solution was extracted with diisopropyl ether (250 ml), the organic solvent was washed with water.After distilling off the solvent, it was isolated and purified by silica gel column chromatography using hexane and ethyl acetate to obtain Compound 3 (2.4 g, yield 56%)
According to the analysis of related databases, 54149-17-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; KURARAY COMPANY LIMITED; SHIBUYA, HIROMASA; MORIHARA, YASUSHI; INAGAKI, TAKUYA; MIURA, MASANORI; FUJITA, AKIO; (25 pag.)JP2015/17052; (2015); A;,
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