Application of 131713-50-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 131713-50-3, name is 2,2-Dimethoxypropan-1-amine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
The precursor 2,2-dimethoxypropylamine can be preparedaccording to the methodology described, for example, in Cui, P.et al., Bioorganic & Medicinal Chemistry Letters, 2006, 16(13),3401-3405. A previously prepared solution of 2,2- dimethoxypropylamine in anhydrous tetrahydrofuran (5.4 g of the amine (41.16 mmol) in 50 mL of the organic solvent) was slowlyadded at a temperature of -5C to the solution obtained according to the methodology described in Comparative Example 6. Once the addition ended, the temperature of the obtained mixture was increased to about 20C, and it was kept under stirring for 16 hours at a temperature of about 20C.Once it no longer had to be kept under the aforementioned conditions, 50 mL of an 8% aqueous NaHCO3 solution and 50 mL of 2-methyltetrahydrofuran were added. The resulting mixture was kept under stirring for about 5 minutes and the resulting organic phase containing (3S)-3-[7-bromo-2-(2,2-dimethoxypropylamino)-5-pyridin-2-yl-3H-benzo[e] [l,4]diazepin-3- yl]propionic acid methyl ester was subsequently separated. The organic solvent was vacuum-distilled, and 50 mL of acetone were added to the resulting residue. The obtained mixture was heated at the reflux temperature and then slowly cooled to about 20C.The resulting solid was filtered and oven-dried, finally obtaining 5.2 g (75.7% from 3-[(3S)-7-bromo-2-oxo-5-(pyridin-2- yl)-2,3-dihydro-1H-[1,4]-benzodiazepin-3-yl] propionic acid methyl ester of formula (D), with a purity of 98.5% by means of UPLC) of (3S)-3-[7-bromo-2-(2,2-dimethoxypropylamino)-5-pyridin- 2-yl-3H-benzo[e] [1,4]diazepin-3-yl]propionic acid methyl ester.Figure 6 shows the 1H-NMR spectrum. 1H-NMR (CDC13, 400 MHz)6 (ppm) : 8.65 (1H, d) , 7.79 (2H, m) , 7.48 (1H, dd) , 7.35 (2H, m)7.10 (1H, d) , 5.18 (1H, m) , 3.70 (3H, s) , 3.64 (1H, dd) , 3.45(1H, dd), 3.31 (1H, dd), 3.22 (3H, s), 3.21 (3H, s), 2.77(1H,m) , 2.65-2.37 (3H, m) , 1.72 (1H, s) , 1.29 (3H, s)Figure 7 shows the 13C-NMR spectrum. 13C-NMR (CDC13, 400MHz) 6(ppm): 173.31, 167.89, 156.77, 154.75, 149.57, 149.16,136.57, 133.78, 133.07, 128.51, 127.10, 124.44, 124.24, 112.33,100.14, 60.24, 51.80, 48.65, 48.62, 45.72, 30.84, 26.23, 20.57.
The synthetic route of 2,2-Dimethoxypropan-1-amine has been constantly updated, and we look forward to future research findings.