Related Products of 59557-91-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 59557-91-4 name is 4-Bromo-2-methoxyaniline, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Example 62 5-(2,3-dichlorobenzyl)-7-{ [2-methoxy-4-(piperidin-4-yl)phenyl]amino} [l ,2,4]triazolo[4,3- c]pyrimidine-8-carboxamide Example 62A feri-butyl 4-(4-amino-3-methoxyphenyl)-5,6-dihydropyridine-l(2//)-carboxylate A mixture of 4-bromo-2-methoxybenzenamine (1.21 g, 6.0 mmol), tert-butyl 4- (3,3,4,4-tetramethylborolan-l -yl)-5,6-dihydropyridine-l (2//)-carboxylate (1.95 g, 6.3 mmol), sodium carbonate (1 .91 g, 18 mmol) and 1 , 1 ‘- bis(diphenylphosphino)ferrocene]dichloropalladium(II) (0.22 g, 0.3 mmol) in dioxane (25 mL) and water (5 mL) was degassed with nitrogen and heated to 90C for 15 hours. After cooling to ambient temperature, the mixutre was filtered, concentrated and purified by flash chromatography eluting with 200: 1 dichloromethane:methanol to give the title compound. MS: 305 (M+Hf).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Bromo-2-methoxyaniline, and friends who are interested can also refer to it.