In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 4393-09-3 as follows. Computed Properties of C9H13NO2
General procedure: To a solution of the acid derivative (1mmol) in CH2Cl2 were added triethylamine (2mmol) and ethyl chloroformate (1mmol), followed by stirring at 0C for 30min. After addition of the appropriate amine derivative (1.2mmol), the mixture was stirred for an additional 1h at 0C. Then, the reaction mixture was warmed to room temperature and stirred overnight. After the solvent was evaporated under reduced pressure, acetone was added, filtered, and evaporated. The residue was dissolved in CH2Cl2, and the organic phase was washed with a 1% NaHCO3 solution and brine, dried over Na2SO4, and evaporated under vacuum. The final residue was purified by flash column chromatography (Combiflash Rf) using CH2Cl2-MeOH (0-5%) as eluents. 4.3.8 (E)-N-(2,3-Dimethoxybenzyl)-3-(1H-indol-3-yl)acrylamide 3h Yield 69%, mp 211-213 C; IR (FTIR/FTNIR-ATR): 1639 cm-1 (C=O), 3206 cm-1 (N-H). 1H NMR (DMSO-d6) delta: 11.56 (1H, s), 8.21 (1H, t, J = 5.6 Hz), 7.91 (1H, d, J = 7.6 Hz), 7.75 (1H, s), 7.63 (1H, d, J = 15.6 Hz), 7.45 (1H, d, J = 7.6 Hz), 7.18 (2H, m), 6.88 (3H, m), 6.71 (1H, d, J = 16 Hz), 4.40 (2H, d, J = 6 Hz), 3.80 (3H, s), 3.76 (3H, s). 13C NMR (DMSO-d6) delta: 166.9, 152.9, 146.9, 138.0, 133.8, 133.5, 131.0, 125.5, 124.5, 122.8, 121.1, 120.9, 120.6, 116.8, 112.9, 112.8, 112.3, 60.8, 56.3, 37.7; HRMS C20H21N2O3 [M+H]+ Calcd 337.1552, Found m/z 337.1544.
According to the analysis of related databases, 4393-09-3, the application of this compound in the production field has become more and more popular.