Related Products of 707-07-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 707-07-3, name is (Trimethoxymethyl)benzene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Compound 18 (1.03 g, 1.77 mmol) was dissolved in dry N,N-dimethylformamide (2 ml) and trimethylorthobenzoate (1.2 ml, 7.08 mmol). The solution was stirred under vacuum (ca 10 mbar) for 10 min then d(+)-camphorsulfonic acid (0.020 g, 0.088 mmol) was added. The mixture was stirred under vacuum for 3 h then triethylamine (0.5 ml) was added and the reaction mixture was concentrated. The residue was dissolved in CH2Cl2, washed with water then the aqueous layer was extracted with CH2Cl2. The combined organic layers were dried (MgSO4), filtered and concentrated.The crude residue was dissolved in dry THF (5 ml) containing n-tetrabutylammonium fluoride (1.67 g, 3.09 mmol). The mixture was stirred at room temperature for 3 h then concentrated. The residue was taken up in CH2Cl2, washed with brine then the aqueous layer was extracted with CH2Cl2. The combined organic layers were dried (MgSO4), filtered and concentrated.To a solution of the previous residue in dry N,N-dimethylformamide (10 ml) was added benzyl bromide (0.65 ml, 3.09 mmol) under argon. The solution was cooled to 0 C then sodium hydride (0.250 g, 3.60 mmol) was added portionwise. The mixture was stirred at room temperature overnight then methanol was added and concentrated. The residue was dissolved in CH2Cl2, washed with brine then the aqueous layer was extracted with CH2Cl2. The combined organic layers were dried (MgSO4), filtered and concentrated.The residue was dissolved in a mixture of THF (5 ml), acetic acid (4 ml) and water (1 ml) and stirred at room temperature for 2 h. The solution was diluted with CH2Cl2 then washed with satd aq NaHCO3. The aqueous layer was extracted with CH2Cl2 then the combined organic layers were dried (MgSO4), filtered and concentrated.
The synthetic route of (Trimethoxymethyl)benzene has been constantly updated, and we look forward to future research findings.