Electric Literature of 50742-37-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 50742-37-5 name is (3-Phenoxyphenyl)methanamine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
C) 3-oxo-2-(3-phenoxybenzyl)isoindoline-5-carbonitrile Under nitrogen atmosphere, a mixture of methyl 2-(bromomethyl)-5-cyanobenzoate (100 mg), 1-(3-phenoxyphenyl)methanamine (94 mg), DIEA (0.082 mL) and THF (7 mL) was stirred at 50C for 6 hr, and then overnight at room temperature, and the reaction mixture was concentrated under reduced pressure. To the residue was added water, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate) to give the title compound (123 mg). MS (API+), found: 341.2 (M+1)
At the same time, in my other blogs, there are other synthetic methods of this type of compound, (3-Phenoxyphenyl)methanamine, and friends who are interested can also refer to it.