Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 168971-68-4, name is 1-Bromo-2-fluoro-4-(trifluoromethoxy)benzene, A new synthetic method of this compound is introduced below., category: ethers-buliding-blocks
To a solution of 1-brorno-2-fiuoro-4-(rifluorornethoxy)benzene (5.00 g, 19.31 mrnoi) in MeCN (20 inL) wasadded NO2BF4 (2.69 g. 2027 mrnoi) in portions keeping the temperature between -40 to -30 C. The mixture was stirred at between -40C to -30C for 2 h. Then the mixture was allowed to warm to rt and stirred for 18 Ii. The mixture was poured into ice, and extracted with EtOAc (3×30 mL). The combined organic layers were dried over Na2SO4, filtrated and concentrated in vacuo, The residue was purified on silica gel (PE:EtOAc=80: ito 50:1) to atihrd the title compound.
The synthetic route of 168971-68-4 has been constantly updated, and we look forward to future research findings.