Synthetic Route of 1663-61-2, A common heterocyclic compound, 1663-61-2, name is (Triethoxymethyl)benzene, molecular formula is C13H20O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
In a round bottomed flask, diol 7 (1.03 g 8.8 mmol) was dissolved in 90 mL of DCM. Triethylorthobenzoate (3.0 mL,13.5 mmol) and p-toluenesulfonic acid (32.0 mg 2 molpercent) were added. The reaction mixture was stirred at room temperature for one hour. Water (0.4 mL) was added and the mixture stirred vigorously for an additional 40 minutes. The solvent was removed in vacuo, and the residue waspurified by silica gel column chromatography using 25percent ethyl acetate/hexanes as the eluent. Benzoate 10(1.02 g, 52percent) was obtained as a yellow oil. 1H-NMR (500 MHz, CDCl3): delta 2.15-2.20 (t, J=6.0 Hz, 1H),3.71-3.78 (dd, J=6.0, 12.0 Hz, 1H), 3.78-3.84 (dd, J= 5.0, 12.0 Hz, 1H), 3.86-3.93 (quin, J=5.0 Hz, 1H),4.44-4.51 (dd, J=7.0, 12.0 Hz, 1H), 4.53-4.59 (dd, J=4.5, 12.0 Hz, 1H), 7.44-7.50 (dd, J=5.0 Hz, 7.0 Hz,2H), 7.57-7.62 (t, J=7.5 Hz, 1H), 8.03-8.09 (d, J=7.5 Hz, 2H).
The synthetic route of 1663-61-2 has been constantly updated, and we look forward to future research findings.