Application of 446-59-3, A common heterocyclic compound, 446-59-3, name is 2-Bromo-1-fluoro-3-methoxybenzene, molecular formula is C7H6BrFO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Intermediate 1-40fluoro-phenol (1-40)To a solution of 2-bromo-3-fluoroanisole [C.A.S. 935285-66-8] (1 g, 4.48) in DCM (2 mL), BBr3 (17.93 mL, 17.93 mmol) was added dropwise at 0C. The reaction was stirred 2 h at r.t. Then the excess of BBr3 was quenched dropwise with water at 0C, the organic layer was separated, dried (Na2S04), filtered and the solvent evaporated in vacuo to yield intermediate 1-40 (0.94 g, quant, yield) that was used as such in the next reaction step
The synthetic route of 446-59-3 has been constantly updated, and we look forward to future research findings.