Reference of 38336-04-8,Some common heterocyclic compound, 38336-04-8, name is 2-(Benzyloxy)-1-ethanamine, molecular formula is C9H13NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Ethyl 2-(4-chloro-3-nitrophenyl)-2-methylpropanoate (3a)(16.15 g, 0.0594 mol), 4 (27.77 g, 0.149 mol), K2CO3 (28.69 g,0.208 mol), KI (0.99 g, 5.94 mmol), TBAB (1.91 g, 5.94 mmol) and150 mL DMSO were added into a round-bottomed flask. The mixturewas heated to 120 C for 24 h then cooling to room temperature.The reaction mixture was diluted with saturated NH4Claqueous solution (250 mL) and extracted with CH2Cl2 (450 mL).The combined organic layer was washed with brine (300 mL), driedover anhydrous sodium sulfate, filtered, and concentrated in vacuo.The residue was purified by silica gel column chromatography (PE:EtOAc = 4:1) to give compound 5a (15.82 g) as yellow oil in 69%yields. 1H NMR (300 MHz, CDCl3) d (ppm) 8.27 (s, 1H), 8.19 (d,J = 2.4 Hz, 1H), 7.41-7.30 (m, 5H), 6.84 (d, J = 9.0 Hz, 1H), 4.61 (s,2H), 4.13 (q, J = 7.1 Hz, 2H), 3.77 (t, J = 5.4 Hz, 2H), 3.53 (q,J = 5.3 Hz, 2H), 1.58 (s, 5H), 1.21 (t, J = 7.1 Hz, 3H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-(Benzyloxy)-1-ethanamine, its application will become more common.