Introduction of a new synthetic route about 2-Fluoro-1,4-dimethoxybenzene

Adding a certain compound to certain chemical reactions, such as: 82830-49-7, name is 2-Fluoro-1,4-dimethoxybenzene, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 82830-49-7, HPLC of Formula: C8H9FO2

EXAMPLE SIXTY-THREE: General Procedure for Iodoaryl Ligand Precursor; General procedure for the synthesis of B, C, D, and E. An oven-dried three-neck round bottom flask, which was equipped with a magnetic stir bar and charged with magnesium shavings (2.4 equiv), was fitted with a reflux condenser, glass stopper, and rubber septum. The flask was purged with argon and then THF (1 mL/mmol) and the bromo arene (2 equiv) were added via syringe. The reaction mixture was heated to reflux and 1 ,2-dibromethane (40 uL) was added via syringe. The reaction was allowed to stir at reflux for 1.5 h and was then cooled to room temperature. A separate oven-dried round bottom flask, which was equipped with a magnetic stir bar and fitted with a septum, was purged with argon and then THF (10 mL/mmol) and 1 ,4-dimethoxy-2-fluorobenzene (1 equiv) were added to the flask via syringe. The reaction mixture was cooled to -78 0C and n-BuLi (1.05 equiv) was added in a dropwise fashion over a 40 min period. The solution was stirred for 1 h and the Grignard reagent, which was prepared in the first reaction vessel, was added via cannula over a 30 min period and allowed to stir at -78 0C for 1 h. The reaction mixture was warmed to room temperature slowly where it was stirred for an additional 12 h. The mixture was then cooled to 0 0C and a solution of Iodine in THF (I M, 2 equiv) was added via syringe over a 15 min period and then the dark red solution was warmed to room temperature and stirred for 1 h. The solvent was removed via a rotary evaporator, and the remaining dark brown oil was taken up in Et2O, washed with a saturated solution of sodium sulfite, and washed with brine. The organic layer was then dried over MgSO4, filtered, and the solvent was removed via rotary evaporator. The crude material was recrystallized to give the desired product.

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