Related Products of 19056-40-7, These common heterocyclic compound, 19056-40-7, name is 4-Bromo-3-methoxyaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To the solution of 4-bromo-3-methoxyaniline (17.4 g, 86.6 mmol) in dichloromethane (117 mL) cooled to 0 °C was added diisopropylethylamine (22.4 g, 173.2 mmol) and the mixture was stirred for 10 mm. To this mixture methylchloroformate (9.8 g, 103.9 mmol) was added dropwise. The reaction mixture was warmed gradually to room temperature and stirring continued for 2 h. Upon completion of the reaction, it was quenched with ice cold water (100 mL) and diluted with ethyl acetate (200 mL). The organic layer was washed with brine solution (100 mL), dried over sodium sulfate and concentrated under reduced pressure to affordmethyl (4-bromo-3-methoxyphenyl)carbamate (13 g, 58percent yield) as light yellow solid. LCMS (ESI) m/e 258.0 [(M), calcd for C9H9BrNO3, 258.0]; LC/MS retention time (method A): tp. = 1.68 min.
Statistics shows that 4-Bromo-3-methoxyaniline is playing an increasingly important role. we look forward to future research findings about 19056-40-7.