Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 29578-39-0, name is 1-Bromo-3-fluoro-5-methoxybenzene, A new synthetic method of this compound is introduced below., category: ethers-buliding-blocks
To a solution of 1-bromo-3-fluoro-5-methoxybenzene (15 g,73.16 rnmol), tris(2-methylphenyl)phosphane (1.781 g, 5.85rnmol) and ethyl acrylate (11.90 mL, 109.74 mmcl) in TEA (135 mL) was added palladium(II) acetate (0.329 g, 1.46 nimnol) at room temperature under nitrogen atmosphere, and the mixturewas stirred at 90C for 2 days. The solvent was evaporated under reduced pressure, the residue was diluted with water, and the mixture was extracted with ethyl acetate. The organic layer was washed with water and brine, and dried overmagnesium sulfate, and the solvent was evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography to give ethyl (E)-3-(3-fluoro-5- methoxyphenyl)acrylate (14.2 g, 63.3 mmcl, 87%) as a colorless oil.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.