These common heterocyclic compound, 82830-49-7, name is 2-Fluoro-1,4-dimethoxybenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 2-Fluoro-1,4-dimethoxybenzene
General procedure: Eaton?s reagent was prepared from phosphorus pentoxide (P2O5) and methanesulfonic acid (CH3SO3H) (weight ratio P2O5/CH3SO3H 1:10). The mixture was heated at 40 C under nitrogen atmosphere until complete homogeneity. Benzoic acid (1.15-1.5 equiv) and aromatic derivative (1.0 equiv) were then added to Eaton?s reagent. The mixture was heated at 50 C under inert atmosphere for 3-14 h. After cooling to room temperature, the reaction medium was diluted with dichloromethane and carefully poured into a separatory funnel containing sodium bicarbonate aqueous solution (50% NaHCO3) (neutralization to pH 7). The aqueous solution was extracted with dichloromethane, and the combined organic layers were dried (MgSO4). Solvent was removed under reduced pressure to produce a brownish oil. The crude product was purified by Flash chromatography on RediSep packed columns to provide pure fluorobenzophenones 7a-f.
The synthetic route of 2-Fluoro-1,4-dimethoxybenzene has been constantly updated, and we look forward to future research findings.
Reference:
Article; Ghinet, Alina; Tourteau, Aurelien; Rigo, Benoit; Stocker, Vivien; Leman, Marie; Farce, Amaury; Dubois, Joelle; Gautret, Philippe; Bioorganic and Medicinal Chemistry; vol. 21; 11; (2013); p. 2932 – 2940;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem