Adding a certain compound to certain chemical reactions, such as: 171290-52-1, name is 3,5-Dimethoxyphenylacetylene, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 171290-52-1, Quality Control of 3,5-Dimethoxyphenylacetylene
General procedure: To a THF solution of CuI (5 mol%) and NiCl2¡¤6H2O (5 mol%), tetramethylethylendiamine (20 mol%) was added. The solution was stirred 2 min at room temperature. C5-Ethynyl-nucleoside (1 eq.) and commercial alkyne (5 eq.) were added subsequently and the reaction mixture was stirred overnight at room temperature under oxygen atmosphere. After evaporation of all volatiles, the residue was purified by silica gel column chromatography (EtOAc/Petroleum ether) to yield the desired compound.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,5-Dimethoxyphenylacetylene, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Sari, Ozkan; Roy, Vincent; Balzarini, Jan; Snoeck, Robert; Andrei, Graciela; Agrofoglio, Luigi A.; European Journal of Medicinal Chemistry; vol. 53; (2012); p. 220 – 228;,
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