Application of 5414-19-7,Some common heterocyclic compound, 5414-19-7, name is 1-Bromo-2-(2-bromoethoxy)ethane, molecular formula is C4H8Br2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: Dimethyl 5-hydroxyisophthalate (1, 6 mmol), 1,omega-dialkylating agent (18 mmol) and K2CO3 (60 mmol) were stirred in anhydrous DMF (60 mL) at a room temperature for 18 h. The reaction mixture was Celite filtered, washed with dichloromethane and toluene. The combined filtrates were evaporated to dryness and the residual colorless oil was chromatographed (dichloromethane, then dichloromethane:methanol, 100:1, v/v) to give a crude product which was a white solid. The yields ranged from 18 to 80%. Some reactants prepared as above have been obtained previously by diverse methods: dimethyl 5-(2-bromoethoxy)isophthalate (2a) [11], dimethyl 5-(5-bromopentoxy)isophthalate (2b) [12] and dimethyl 5-(3-bromopropoxy)isophthalate (2d) [13].
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Bromo-2-(2-bromoethoxy)ethane, its application will become more common.
Reference:
Article; Gierszewski, Mateusz; Falkowski, Michal; Sobotta, Lukasz; Stolarska, Magdalena; Popenda, Lukasz; Lijewski, Sebastian; Wicher, Barbara; Burdzinski, Gotard; Karolczak, Jerzy; Jurga, Stefan; Gdaniec, Maria; Tykarska, Ewa; Sikorski, Marek; Mielcarek, Jadwiga; Goslinski, Tomasz; Journal of Photochemistry and Photobiology A: Chemistry; vol. 307-308; (2015); p. 54 – 67;,
Ether – Wikipedia,
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