Chemistry is an experimental science, Quality Control of 1-Bromo-2-methoxybenzene, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 578-57-4, Name is 1-Bromo-2-methoxybenzene, molecular formula is C7H7BrO, belongs to ethers-buliding-blocks compound. In a document, author is Skuredina, Anna A..
The formation of quasi-regular polymeric network of cross-linked sulfobutyl ether derivative of beta-cyclodextrin synthesized with moxifloxacin as a template
Sulfobutyl ether derivative of beta-cyclodextrin, cross-linked in the presence of antibacterial drug moxifloxacin, forms polymeric nanoparticles (50-150 nm in diameter), with highly efficient (up to 85%) encapsulation of the drug. Cyclodextrins (CyDs) have been known for their ability to accommodate a wide range of organic molecules in their inner cavity, leading to guest-host inclusion complexes. Here, we show that in the case of highly cross-linked complex a substantial part of moxifloxacin molecules can be captured by the polymer’s network (i.e. encapsulated in the growing 3D structure) rather than absorbed by the CyD’s inner cavity. This is accompanied by dramatic changes in moxifloxacin’s release kinetics profile: depending on pH, 30-100% of the drug is released from the polymer network within a week. Whereas in the case of moxifloxacin absorption on pre-synthesized CyD polymer matrix, 50% release normally occurs within hours. In vitro studies on Escherichia coli demonstrate that the moxifloxacin in highly cross-linked nanoparticle can preserve over 50% of antibacterial activity for at least 7 days, whereas the same amount of free moxifloxacin, as well as its guest-host complex with CyD, is inactive at this time point. The nanoparticles’ ability to adhere to the bacterial cell wall may contribute to the higher activity of the smaller amount of the drug, emphasizing the potential relevance of this approach for the development of new pharmaceutical formulations.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 578-57-4. Quality Control of 1-Bromo-2-methoxybenzene.